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nirE nirE hemC hemC Dshi_1155 Dshi_1155 cysG cysG cobI cobI cysC cysC hemD hemD hemE hemE nirJ nirJ nirH nirH nirG nirG
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nirETIGRFAM: uroporphyrin-III C-methyltransferase PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase KEGG: sil:SPOA0221 nitrite reductase heme biosynthesis E protein rde:RD1_1566 nirE; uroporphyrin-III C-methyltransferase; Urogen III methylase; Belongs to the precorrin methyltransferase family. (264 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.986
Dshi_1155
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
 
 
0.949
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
 
 
0.948
cobI
TIGRFAM: precorrin-2 C20-methyltransferase PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase KEGG: mag:amb0297 precorrin-2 methylase; alternative gene name: cbiL; Belongs to the precorrin methyltransferase family.
 
 
0.930
cysC
Putative bifunctional SAT/APS kinase: sulfate adenylyltransferase; Catalyzes the synthesis of activated sulfate.
  
  
 0.921
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.918
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.914
nirJ
Putative nitrite reductase heme biosynthesis J protein; PFAM: Radical SAM domain protein SMART: Elongator protein 3/MiaB/NifB KEGG: sil:SPOA0227 nitrite reductase heme biosynthesis J protein.
  
 0.877
nirH
KEGG: sil:SPOA0226 nitrite reductase heme biosynthesis H protein, COG1522 - Transcriptional regulators.
 
  
 0.862
nirG
Nitrite reductase heme biosynthesis G; SMART: regulatory protein AsnC/Lrp family KEGG: rde:RD1_1570 nitrite reductase heme biosynthesis G.
 
    0.860
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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